2100 mile drive one shot?

Not even possible, that should be a three day drive.

Yes, there is a way out of it. You just can't see it, that's all.

Going on a short trip needs a plan when to stop for Fuel and a feed

you can do 800 miles in day But you won't do 400 miles the second day unless you have 2 drivers then you can do 1800 Miles in 2 days

After 24-26 hours without sleep, you should expect to crash and wreck the car and possibly die.

I did 26 hours straight twice a few years ago over a weekend. I had to clean out my mothers house. Left after work on Friday, returned on Sunday. I was seeing double and couldn't keep my pickup truck between the lines for the last 30 miles on my way home. I know you gotta do what you gotta do, but I don't recommend it. Be careful and good luck.

I hope this is a troll post. Fist off it will take you much longer than 28 hours. Just because Mapquest’s says 1 day 6 hours doesn’t mean that is the correct amount of time for the trip. It does not account for traffic, road conditions, detours, speed limits, getting gasoline, rest stops, eating, weather.

You are fool to think you will be doing an average speed of 75 mph.  

And you need to do the southern route. Through Texas New Mexico and Arizona if you are driving in the next couple of months.

Expect to have to stop to sleep for 5-8 hours at least twice.

Expect this to take twice  as long.

What to expect, the best time you can expect is about 33/34 hours drive time. There is not any way you can average 75 MPH unless you are driving 90 to 100 MPH a lot of the time. But of course that far and those extra high speeds you may have to stop for the red light behind you. Now are you saying you can stay awake that long and still be driving safely? What you think is not going to happen. 

You stand an excellent chance of not making it at all if you try that. Especially in winter, on unfamiliar roads, in the dark, and a good portion of it in mountains. I think what you can expect is to pile up your car some time in the last half of the trip. Even if you manage an average of 75 mph while you are actually driving, supposing you don't run into a snowstorm, a construction zone, or just plain heavy traffic, you will need to stop to get gas, to pee, to get food or coffee. That will increase the time the whole trip takes so to get there in 28 hours you'd have to drive even faster and that will increases your chances of having an accident and increase your chances of having a fatal one. Fatal to you and/or someone else.

Truck drivers in the US are limited to 11 hours on the road at a time. What to guess why? And these are the people who drive long hours every working day all year long.

They're used to doing it. If you are asking this question, then you are clearly NOT used to long distance driving.

Death can be expected. I am the King of Long Drives and 17 hours nearly did me in.

The only way you will live thru this is if you are a troll.

And PLEASE ignore my idiocy and listen to the OTHER answerers here.

This is a spectacularly BAD idea.

One, there is no way you will be safe to drive due to fatigue over such a long drive time.

Two, there is no way you will be able to maintain such an average ground covered rate. You will need to stop to pee, to get gas, and to get food.

Three, a good part of that route includes roads with deer and the like out at night, and your odds to hit one would only increase with your gross fatigue.

Change your plans. Arrive alive.